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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T5689 | 20-DEOXYINGENOL | Others , Autophagy | |
20-DEOXYINGENOL is a natual product. | |||
T6207 | SC144 | Apoptosis , Interleukin | |
SC144 is an orally active small-molecule gp130 inhibitor. | |||
T28362 | PF-02413873 | PF02413873 | Progesterone Receptor |
PF-02413873 is a competitive antagonist of nonsteroidal progesterone receptor with a Ki of 2.6 nM. PF-02413873 can be used in studies about the treatment of gynecological conditions such as endometriosis. | |||
T8730 | BMS986260 | TGF-beta/Smad | |
BMS-986260 is a selective, and orally bioavailable TGFβR1 inhibitor(IC50 = 1.6 nM). | |||
T83727 | Tat-NTS Peptide TFA | Tat-Nuclear Translocation Signal Peptide | |
Tat-NTS peptide, a cell-penetrating compound, comprises the HIV-1 Tat protein transduction domain fused with a 10-amino acid sequence (residues 228-237) from the repeat III domain of annexin A1, serving as a nuclear tran... | |||
T19768 | γ-Tocotrienol | gamma Tocotrienol,gammaTocotrienol,gamma-Tocotrienol,D-gamma-Tocotrienol,Plastochromanol | Others |
γ-Tocotrienol (Plastochromanol) is one of the four types of tocotrienol, a type of vitamin E. Itl is also a radioprotector, antioxidant. It shows antitumor and antihypertensive effects in vivo. | |||
T2008 | LY294002 | LY 294002,NSC 697286,SF 1101 | Apoptosis , DNA-PK , Casein Kinase , PI3K , Autophagy |
LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM). LY294002 is also an inhibitor of DNA-PK (IC50=1.4 μM) and an inhibitor of CK2 (IC50=98 nM). LY294002 ... | |||
T4079 | LY-294002 hydrochloride | SF 1101,LY 294002,NSC 697286 | PI3K |
LY-294002 hydrochloride (NSC 697286) is a synthetic molecule inhibitor of PI3Kα/δ/β (IC50: 0.5/0.57/0.97 μM, in cell-free assays); more stable than Wortmannin in solution, and also is a blocker of autophagosome formation... | |||
T11886 | LTβR-IN-1 | Others , NF-κB , LTR | |
LTβR-IN-1 is a potent and selective lymphin β receptor (LTβR) inhibitor. LTβR-IN-1 has a selective inhibitory effect on the nuclear translocation of p52 of TNF12A, and has no obvious effect on the nuclear translocation o... | |||
T6915 | Darolutamide | ODM-201,BAY-1841788 | Androgen Receptor |
Darolutamide (BAY-1841788) is an androgen receptor (AR) antagonist that blocks AR nuclear translocation (Ki: 11 nM). | |||
T4657 | WHI-P97 | JAK | |
WHI-P97 is a rationally designed potent inhibitor of JAK-3. IC50 value: Target: JAK3 Treatment of mast cells with WHI-P97 inhibited the translocation of 5-lipoxygenase (5-LO) from the nucleoplasm to the nuclear membrane ... | |||
T5701 | OPHIOPOGONIN D | RAAS , Calcium Channel , NF-κB , PPAR | |
Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation. | |||
T6308 | Stattic | STAT3 Inhibitor V | Apoptosis , STAT |
Stattic (STAT3 Inhibitor V) is a STAT3 inhibitor (IC50=5.1 μM) that selectively inhibits STAT3 activation, dimerization, and nuclear translocation. Stattic has antitumor activity and induces apoptosis. | |||
T4022 | QS11 | QS 11 | GTPase |
QS11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. Modulates ARF-GTP levels and synergizes with the Wnt/β-catenin signaling pathway to upregulate β-catenin nuclear translocation. Also r... | |||
T61531 | NFATc1-IN-1 | RANKL/RANK | |
NFATc1-IN-1 (also known as compound A04) is a highly effective inhibitor of osteoclast formation induced by RANKL, with an IC50 of 1.57 μM. It exerts its anti-osteoclastogenic effects by attenuating the RANKL-induced nuc... | |||
T11760 | KIN101 | 3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene | HCV Protease , Influenza Virus , RSV , Antifection |
KIN101 (3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene), an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has antiviral activity against RNA viruses, HCV, and R... | |||
T4237 | Rubiadin-1-methyl ether | Rubiadin 1-methyl ether | Anti-infection , NF-κB |
Rubiadin-1-methyl ether (Rubiadin 1-methyl ether) is a natural product.It inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of IκBα as well as decrease in the nu... | |||
TP1938L | RS09 2TFA (1449566-36-2 free base) | RS09 2TFA 1449566-36-2(free base) | TLR |
RS09 2TFA (1449566-36-2 free base) is a TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. It acts as an adjuvant in vivo and enhances X-15 sp... | |||
T77332 | TV 3279 | BCL , PKC | |
TV 3279 is a novel ChE-MAI inhibitor , and the neuroprotective properties depend on their ability to induce the anti-apoptotic proteins PKC, Bcl-2, Bcl-x, and SOD, and to block the nuclear translocation of the pro-apopto... | |||
T8055 | TFEB activator 1 | (1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,,Curcumin analog compound C1,Curcumin analog C1,RPN77612 | Others , Autophagy |
TFEB activator 1 (Curcumin analog compound C1) is an activator of transcription factor EB (TFEB) with promise for the prevention or treatment of Alzheimer's disease. |